a radical change in the way drugs are delivered to targets

Water soluble active pharmaceutical ingredients pose a number of delivery challenges such as poor bioavailability and poor cellular penetration efficiencies resulting in the need for elevated doses which in turn may cause safety and/or tolerability issues. In the cases of advanced therapeutics such as peptides, invasive administration routes combined with extensive chemical modifications are needed to obtain satisfactory delivery, again resulting in increased toxicity and patient tolerability.

Aonys^® is a unique delivery technology which provides water-soluble drugs:

• Improvements in drug bioavailability
• Improvements in pharmacokinetic profiles
• Improvement in cellular penetration efficiencies
• Efficient CNS penetration
• A buccal mucosa route of administration for biomolecules

resulting in:

• Decreases in active doses
• Improved safety and tolerability profiles
• A comfortable route of administration and increased patient compliance

Learn more about how Medesis employs Aonys^® technology in our preclinical and clinical research programs and how to employ this technology in your own research programs through our Technology Access Program.