Neurology

Although causes may be multiple, many of the underlying mechanisms leading to neuron death are common giving hope for research into this group of debilitating diseases.

Neurodegeneration - an unsolved problem

The prevalence of neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease is increasing, but effective treatments are lacking. Researchers have revealed many common cellular pathways among this diverse group of disorders, including protein aggregation and mitochondrial dysfunction. Lithium has been used for many years as a mood stabiliser and a successful treatment for bipolar disorder, mania and depression.  More recent studies have shown that lithium has activity in neuroprotection through a variety of complex pathways opening new avenues for research into this debilitating group of diseases.

Huntington’s Disease

Huntington’s disease is a fatal hereditary disease affecting 1 in 10,000 individuals with first symptoms normally appearing in both men and women between 30 and 40 years of age.  Genetic defects result in the production of an abnormal huntingtin protein which disrupts normal neurogenesis and eventually leads to neurone death.  This in time leads to atrophy in various parts of the brain, particularly in the striatum which is involved in motor function, which eventually results in the group of symptoms associated with Huntington’s disease. Medesis Pharma is currently developing NP03, a combination of lithium and Aonys.  The application of NP03 to other neurodegenerative pathologies is currently under investigation.