AONYS® is a mix of lipidic components that spontaneously assemble into a water-in-oil microemulsion. The active agent is solubilized in the aqueous phase of the microemulsion, within reverse micelles of 3 to 5 nm in diameter. AONYS® allows the administration of low...
Buccal administration No first pass-hepatic degradation Passage through the BBB No exposure to plasmatic and interstitial degradation enzymes Increased benefit/risk ratio Superior pharmacokinetic profile with increased efficacy coupled with better tolerability Low...
The AONYS® platform is able to formulate water soluble active ingredients of various sizes such as metal ions, chelating molecules, peptides and oligonucleotides. In addition, stable ultra-small nanoparticles may be manufactured in situ, opening up new opportunities...
9 international patents protect the formulation and its multiple therapeutic applications: Title : In situ preparation of cyano-bridged metal nanoparticles within a biocompatible reverse micellar system Priority : 07/09/2015 PCT Publication : WO 2017/005899A1,...
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